HEART’s integrated approach aims to systematically improve urban health and reduce health disparities through an innovative Blue-Green-Solutions-based implementation mechanisms of urban planning that embraces and promotes the health and the wellbeing as a key-planning criterion. HEART aims to use medical evidence in clinical and non-clinical setting. For all clinical studies a sufficient ground of individuals will be selected to participate. Each case study will include approx. 800 individuals that will be selected by the medical and social experts of the consortium under the supervision of the local medical centers.